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Body composition — more to fat than first meets the eye

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Body composition and fitness have important roles in predicting prognosis in both primary and secondary prevention of cardiovascular diseases. Additionally, in patients with established cardiovascular diseases, body composition and fitness impact partly explain the ‘obesity paradox’.

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References

  1. Jenkins, D. A. et al. Adiposity-mortality relationships in type 2 diabetes, coronary heart disease and cancer subgroups in the UK Biobank, and their modification by smoking. Diabetes Care https://doi.org/10.2337/dc17-2508 (2018).

    Article  Google Scholar 

  2. Lee, D. H. et al. Predicted lean body mass, fat mass, and all cause and cause specific mortality in men: prospective US cohort study. BMJ 362, k2575 (2018).

    Article  Google Scholar 

  3. Lavie, C. J. et al. Obesity and prevalence of cardiovascular diseases and prognosis: the obesity paradox updated. Prog. Cardiovasc. Dis. 58, 537–547 (2016).

    Article  Google Scholar 

  4. Lavie, C. J. et al. Update on obesity and obesity paradox in heart failure. Prog. Cardiovasc. Dis. 58, 393–400 (2016).

    Article  Google Scholar 

  5. Lavie, C. J., De Schutter, A., Patel, D., Artham, S. M. & Milani, R. V. Body composition and coronary heart disease mortality: an obesity or a lean paradox? Mayo Clin. Proc. 86, 857–864 (2011).

    Article  CAS  Google Scholar 

  6. Lavie, C. J. et al. Body composition and survival in stable coronary heart disease: impact of lean mass index and body fat in the “obesity paradox.” J. Am. Coll. Cardiol. 60, 1374–1380 (2012).

    Article  Google Scholar 

  7. McAuley, P. A. et al. The obesity paradox, cardiorespiratory fitness, and coronary heart disease. Mayo Clin. Proc. 87, 443–451 (2012).

    Article  Google Scholar 

  8. Ortega, F. B., Sui, X., Lavie, C. J. & Blair, S. N. Body mass index, the most widely used but also widely criticized index: would a criterion standard measure of total body fat be a better predictor of cardiovascular disease mortality? Mayo Clin. Proc. 91, 443–455 (2016).

    Article  Google Scholar 

  9. Oktay, A. A. et al. The interaction of cardiorespiratory fitness with obesity and the obesity paradox in cardiovascular disease. Prog. Cardiovasc. Dis. 60, 30–44 (2017).

    Article  Google Scholar 

Download references

Acknowledgements

F.B.O.’s research activity is currently being supported by the Spanish Ministry of Economy and Competitiveness and FEDER (DEP2016-79512-R), and receives additional funding from the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Unit of Excellence on Exercise and Health (UCEES) and the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 667302.

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Authors and Affiliations

  1. John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA, USA

    Carl J. Lavie

  2. PROmoting FITness and Health through Physical Activity (PROFITH) research group, Department of Physical Education and Sports Faculty of Sport Sciences, University of Granada, Granada, Spain

    Francisco B. Ortega

Authors
  1. Carl J. Lavie
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  2. Francisco B. Ortega
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Correspondence to Carl J. Lavie.

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The authors declare no competing interests.

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Lavie, C.J., Ortega, F.B. Body composition — more to fat than first meets the eye. Nat Rev Endocrinol 14, 569–570 (2018). https://doi.org/10.1038/s41574-018-0088-z

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