Over the past decade, iterative improvements to models predicting breast cancer risk have primarily come from new information about genetic risk factors and improvements to mammogram-based risk scores. Epigenetic risk factors offer some potential to further improve risk stratification. However, the recently developed DNA methylation score (the WID-BC index) is not yet convincing for predicting breast cancer risk.
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The authors thank J. Hopper and S. Li at the University of Melbourne for their helpful discussions whilst preparing this article.
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Southey, M.C., Dugué, PA. Improving breast cancer risk prediction with epigenetic risk factors. Nat Rev Clin Oncol 19, 363–364 (2022). https://doi.org/10.1038/s41571-022-00622-4
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DOI: https://doi.org/10.1038/s41571-022-00622-4
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