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LUNG CANCER

Liquid biopsy for early stage lung cancer moves ever closer

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Lung cancer screening is currently based only on low-dose CT scans; however, novel, more accessible methods that might improve uptake and adherence are eagerly awaited. New liquid biopsy approaches promise to revolutionize cancer screening. Herein, we discuss the opportunities and challenges associated with two such novel assays.

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Fig. 1: Liquid biopsy for early lung cancer detection.

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Acknowledgements

We thank Umberto Malapelle and Diego de Miguel Perez for their helpful suggestions during manuscript preparation.

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Authors and Affiliations

  1. Thoracic Oncology & Experimental Therapeutics Program, Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA

    Christian Rolfo & Alessandro Russo

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  1. Christian Rolfo
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  2. Alessandro Russo
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Corresponding author

Correspondence to Christian Rolfo.

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Competing interests

C.R. has received speakers’ bureau from AstraZeneca and MSD, a research grant from the Lung Cancer Research Foundation–Pfizer, and research support from Guardant Health and Biomark; has an advisory board role with ARCHER, Inivata and Merck Serono; and has consulted for Mylan and Oncopass. A.R declares no competing interests.

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Rolfo, C., Russo, A. Liquid biopsy for early stage lung cancer moves ever closer. Nat Rev Clin Oncol 17, 523–524 (2020). https://doi.org/10.1038/s41571-020-0393-z

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