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Mosaic loss of chromosome Y and cardiovascular disease

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From Nature Reviews Cardiology

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Mosaic loss of chromosome Y (mLOY) refers to the condition in male individuals in which a detectable fraction of cells lose the Y chromosome. Prevalent in haematopoietic cells, this common somatic mutation is associated with decreased longevity and an increased risk of age-related diseases, including cardiovascular disease. Haematopoietic mLOY provides further insight into the sex-specific disparities that exist in disease susceptibility.

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Fig. 1: Haematopoietic mLOY is associated with ageing and cardiovascular disease.

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Authors and Affiliations

  1. Laboratory of Cardiovascular Mosaicism, National Cerebral and Cardiovascular Center, Suita, Japan

    Soichi Sano

  2. Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA

    Kenneth Walsh

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  1. Soichi Sano
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  2. Kenneth Walsh
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Correspondence to Kenneth Walsh.

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The authors declare no competing interests.

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Sano, S., Walsh, K. Mosaic loss of chromosome Y and cardiovascular disease. Nat Rev Cardiol 21, 151–152 (2024). https://doi.org/10.1038/s41569-023-00976-x

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  • DOI: https://doi.org/10.1038/s41569-023-00976-x

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