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How cells dig a hole for themselves

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Epithelial tissues cover our organs and play an important role as physical barriers. The conditions leading to spontaneous hole formation in monolayer epithelia, which challenge epithelial integrity, have now been revealed.

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Fig. 1: Monolayer integrity depends on substrate stiffness.

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Correspondence to Tatiana Merle or Magali Suzanne.

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Merle, T., Suzanne, M. How cells dig a hole for themselves. Nat. Phys. 19, 23–24 (2023). https://doi.org/10.1038/s41567-022-01881-9

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