A non-common-path interferometric scheme enables holographic detection of single proteins of mass 90 kDa and estimation of single-protein polarizability.
This is a preview of subscription content, log in via an institution to check access.
References
Young, G. & Kukura, P. Annu. Rev. Phys. Chem. 70, 301–322 (2019).
Taylor, R. W. & Sandoghdar, V. Nano Lett. 19, 4827–4835 (2019).
Piliarik, M. & Sandoghdar, V. Nat. Commun. 5, 4495 (2014).
Ortega Arroyo, J. et al. Nano Lett. 14, 2065–2070 (2014).
Young, G. et al. Science 360, 423–427 (2018).
Thiele, J. C., Pfitzner, E. & Kukura, P. Nat. Photon. https://doi.org/10.1038/s41566-024-01405-2 (2024).
Bian, K. et al. Nat. Rev. Methods Primers 1, 36 (2021).
Yu, D. et al. Nat. Rev. Methods Primers 1, 83 (2021).
Anker, J. N. et al. Nat. Mater. 7, 442–453 (2008).
Howorka, S. & Siwy, Z. Chem. Soc. Rev. 38, 2360–2384 (2009).
Squires, A. H., Lavania, A. A., Dahlberg, P. D. & Moerner, W. E. Nano Lett. 19, 4112–4117 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Hsieh, CL. Single protein imaging with holography. Nat. Photon. 18, 303–304 (2024). https://doi.org/10.1038/s41566-024-01407-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41566-024-01407-0
- Springer Nature Limited