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Protein sequencing

Topographic fingerprinting of single proteins and proteoforms

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A distance-based mapping strategy using single-molecule fluorescence resonance energy transfer via DNA eXchange (FRET X) enables full-length fingerprinting of intact protein sequences.

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Fig. 1: FRET X allows the fingerprinting of full-length intact proteins.

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Authors and Affiliations

  1. Centre of Biophotonics, Laboratory for Biophysics and Biomolecular Dynamics, School of Physics and Astronomy and School of Biology, University of St. Andrews, St Andrews, UK

    J. Carlos Penedo

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  1. J. Carlos Penedo
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Correspondence to J. Carlos Penedo.

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Penedo, J.C. Topographic fingerprinting of single proteins and proteoforms. Nat. Nanotechnol. 19, 580–581 (2024). https://doi.org/10.1038/s41565-024-01638-w

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