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DNA nanotechnology

Shaken, not heated: DNA self-assembly at room temperature

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DNA-origami nanostructures self-assembled at milder physicochemical parameters in magnesium-free conditions achieve structural complexities akin to those formed by thermal annealing at elevated temperatures, and open a route to assembling DNA nanomachines in physiological conditions.

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Fig. 1: DNA-origami fabrication in TANa buffer.

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Authors and Affiliations

  1. Department of Mechanical and Aerospace Engineering, University of California at Los Angeles, Los Angeles, CA, USA

    Elisa Franco

  2. Department of Bioengineering, University of California at Los Angeles, Los Angeles, CA, USA

    Elisa Franco

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  1. Elisa Franco
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Correspondence to Elisa Franco.

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Franco, E. Shaken, not heated: DNA self-assembly at room temperature. Nat. Nanotechnol. 18, 1257–1258 (2023). https://doi.org/10.1038/s41565-023-01467-3

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