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Primal FEAR protects against infection

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FEAR is an ancestral histone chaperone complex that can control virus infections in an interferon-independent manner.

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Fig. 1: IFN versus FEAR response mechanisms.

References

  1. Yu, H., Bruneau, R. C., Brennan, G. & Rothenburg, S. Biomedicines 9, 765 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Eaglesham, J. B., McCarty, K. L. & Kranzusch, P. J. eLife 9, e59753 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Secombes, C. J. & Zou, J. Front. Immunol. 8, 209 (2016).

    Google Scholar 

  4. Rex, E. A. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-024-01646-5 (2024).

    Article  PubMed  Google Scholar 

  5. Chen, Q., Sun, L. & Chen, Z. J. Nat. Immunol. 17, 1142–1149 (2016).

    Article  CAS  PubMed  Google Scholar 

  6. Gammon, D. B. et al. eLife 3, e02910 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Wang, P., Yang, W., Zhao, S. & Nashun, B. Cell Cycle 20, 465–479 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Dembowski, J. A. & DeLuca, N. A. PLoS Pathog. 11, e1004939 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  9. O’Connor, C. M., Nukui, M., Gurova, K. V. & Murphy, E. A. J. Virol. 90, 4249–4253 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Winans, S. et al. J. Virol. https://doi.org/10.1128/jvi.00082-17 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

Work in the Walsh lab is supported by funding from the National Institutes of Health, grant numbers R01 AI127456, R01 AI179744 and R01 AI141470.

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  1. Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Derek Walsh

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  1. Derek Walsh
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Correspondence to Derek Walsh.

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The author declares no competing interests.

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Walsh, D. Primal FEAR protects against infection. Nat Microbiol 9, 886–888 (2024). https://doi.org/10.1038/s41564-024-01649-2

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