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Microbial regulation of cholesterol homeostasis

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Commensal gut bacteria harbour sulfotransferases that metabolize cholesterol and some steroid hormones to produce bacterially derived signals that influence host phenotypes.

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Fig. 1: Commensal gut microbes shape cholesterol homeostasis.

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Authors and Affiliations

  1. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, USA

    William J. Massey & J. Mark Brown

  2. Center for Microbiome and Human Health, Lerner Research Institute of the Cleveland Clinic, Cleveland, OH, USA

    William J. Massey & J. Mark Brown

Authors
  1. William J. Massey
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  2. J. Mark Brown
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Correspondence to William J. Massey or J. Mark Brown.

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The authors declare no competing interests.

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Massey, W.J., Brown, J.M. Microbial regulation of cholesterol homeostasis. Nat Microbiol 7, 1327–1328 (2022). https://doi.org/10.1038/s41564-022-01186-w

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