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HOST RESPONSE

Mycobacterium tuberculosis remodels host transcriptome

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An Author Correction to this article was published on 25 February 2022

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Infection by Mycobacterium tuberculosis (Mtb) induces remodelling of the host-cell transcriptome, which is mediated by epigenetic mechanisms. Histone acetylation of KCNJ15 stimulates transcription and the activation of genes implicated in apoptosis to promote Mtb clearance.

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Fig. 1: Proposed host response mechanism mediated by KCNJ15 histone acetylation after infection of monocytes with Mtb.

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Authors and Affiliations

  1. Department of Neuroscience, Developmental and Regenerative Biology, University of Texas at San Antonio, San Antonio, TX, USA

    Melanie A. Carless

  2. Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, TX, USA

    Larry S. Schlesinger

Authors
  1. Melanie A. Carless
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  2. Larry S. Schlesinger
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Correspondence to Larry S. Schlesinger.

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The authors declare no competing interests.

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Carless, M.A., Schlesinger, L.S. Mycobacterium tuberculosis remodels host transcriptome. Nat Microbiol 7, 189–190 (2022). https://doi.org/10.1038/s41564-021-01056-x

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