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Linking anaerobic gut bacteria and cardiovascular disease

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Cooperative interaction between low-abundance gut bacteria is required to convert l-carnitine to TMAO via a multi-step pathway, which leads to an increased risk of cardiovascular disease.

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Fig. 1: The conversion of l-carnitine to TMAO in an anoxic environment.

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Authors and Affiliations

  1. Department of Pediatrics, University of California, San Diego, San Diego, CA, USA

    Joanna Coker, Livia S. Zaramela & Karsten Zengler

  2. Center for Microbiome Innovation, University of California, San Diego, San Diego, CA, USA

    Karsten Zengler

Authors
  1. Joanna Coker
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  2. Livia S. Zaramela
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  3. Karsten Zengler
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Correspondence to Karsten Zengler.

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The authors declare no competing interests.

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Coker, J., Zaramela, L.S. & Zengler, K. Linking anaerobic gut bacteria and cardiovascular disease. Nat Microbiol 7, 14–15 (2022). https://doi.org/10.1038/s41564-021-01009-4

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