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Cholesterol access aids pathogen spread

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Some cytosolic bacteria deform the plasma membrane to spread from cell to cell. Secretion of 25-hydroxy-cholesterol by macrophages has emerged as a protective response that depletes the cholesterol pool used by these bacteria to disseminate through epithelia.

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Fig. 1: Oxysterol-mediated host protection against cytosolic bacteria.

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  1. Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA

    Norma W. Andrews

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  1. Norma W. Andrews
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Correspondence to Norma W. Andrews.

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Andrews, N.W. Cholesterol access aids pathogen spread. Nat Microbiol 5, 881–882 (2020). https://doi.org/10.1038/s41564-020-0744-7

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