Skip to main content
Log in

BACTERIAL PHYSIOLOGY

RNA synthesis is a team effort

  • News & Views
  • Published:

From Nature Microbiology

View current issue Submit your manuscript

Some RNAs have to be made at maximal achievable rates, yet RNA polymerase encounters many obstacles that slow it down. A new study shows that a group of co-transcribing RNA polymerases communicate over long distances to work more efficiently than a solo enzyme.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Factors that control the RNA synthesis rate.

References

  1. Liu, L. F. & Wang, J. C. Proc. Natl Acad. Sci. USA 84, 7024–7027 (1987).

    Article  CAS  Google Scholar 

  2. Boudreau, B. A. et al. Nucleic Acids Res. 46, 5525–5546 (2018).

    Article  CAS  Google Scholar 

  3. Ma, J. et al. Proc. Natl Acad. Sci. USA 116, 2583–2588 (2019).

    Article  CAS  Google Scholar 

  4. Kang, J. Y., Mishanina, T. V., Landick, R. & Darst, S. A. J. Mol. Biol. https://doi.org/10.1016/j.jmb.2019.07.017 (2019).

    Article  PubMed  Google Scholar 

  5. Epshtein, V. & Nudler, E. Science 300, 801–805 (2003).

    Article  CAS  Google Scholar 

  6. Kulaeva, O. I., Hsieh, F. K., Chang, H. W., Luse, D. S. & Studitsky, V. M. Biochim. Biophys. Acta 1829, 76–83 (2013).

    Article  CAS  Google Scholar 

  7. Dennis, P. P., Ehrenberg, M., Fange, D. & Bremer, H. J. Bacteriol. 191, 3740–3746 (2009).

    Article  CAS  Google Scholar 

  8. Gotta, S. L., Miller, O. L. Jr. & French, S. L. J. Bacteriol. 173, 6647–6649 (1991).

    Article  CAS  Google Scholar 

  9. Tantale, K. et al. Nat. Commun. 7, 12248 (2016).

    Article  CAS  Google Scholar 

  10. Heberling, T., Davis, L., Gedeon, J., Morgan, C. & Gedeon, T. PLoS Comput. Biol. 12, e1005069 (2016).

    Article  Google Scholar 

  11. Kim, S., Beltran, B., Irnov, I. & Jacobs-Wagner, C. Cell 179, 106–119 (2019).

    Article  CAS  Google Scholar 

  12. Meyer, S., Reverchon, S., Nasser, W. & Muskhelishvili, G. Curr. Genet. 64, 555–565 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Irina Artsimovitch.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Artsimovitch, I. RNA synthesis is a team effort. Nat Microbiol 4, 1776–1777 (2019). https://doi.org/10.1038/s41564-019-0600-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-019-0600-9

  • Springer Nature Limited

Navigation