Host cells assemble linear ubiquitin chains to activate immune signalling during bacterial infection. A new study reveals that Legionella pneumophila — the causative agent of Legionnaires’ disease — produces an enzyme that specifically disassembles these linear ubiquitin modifications to restrict immune responses.
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Damgaard, R.B., Pruneda, J.N. Legionella dismantles linear ubiquitin. Nat Microbiol 4, 1244–1245 (2019). https://doi.org/10.1038/s41564-019-0515-5
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DOI: https://doi.org/10.1038/s41564-019-0515-5
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