Skip to main content
SpringerLink
Log in

ANTIMICROBIALS

Anti-psychotic drugs block meningococcal virulence

  • News & Views
  • Published:

From Nature Microbiology

View current issue Submit your manuscript

A class of drugs approved to treat schizophrenia can cause rapid loss of the pilus, an essential virulence factor necessary for the disease-causing properties in the strict human pathogen Neisseria meningitidis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Phenothiazines inhibit T4p functions.

References

  1. Berry, J.-L. & Pelicic, V. FEMS Microbiol. Rev. 39, 134–154 (2015).

    Article  CAS  Google Scholar 

  2. Maier, B., Potter, L., So, M., Seifert, H. S. & Sheetz, M. P. Proc. Natl Acad. Sci. USA 99, 16012–16017 (2002).

    Article  CAS  Google Scholar 

  3. Denis, K. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-019-0395-8 (2019).

    Article  PubMed  Google Scholar 

  4. Varga, B. et al. Anticancer Res. 37, 5983–5993 (2017).

    CAS  PubMed  Google Scholar 

  5. Peabody, C. R. et al. Microbiology 149, 3051–3072 (2003).

    Article  CAS  Google Scholar 

  6. Ohlow, M. J. & Moosmann, B. Drug Discov. Today 16, 119–131 (2011).

    Article  CAS  Google Scholar 

  7. Aubey, F. et al. Proc. Natl Acad. Sci. USA 116, 8481–8486 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    H Steven Seifert

Authors
  1. H Steven Seifert
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to H Steven Seifert.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Seifert, H.S. Anti-psychotic drugs block meningococcal virulence. Nat Microbiol 4, 906–907 (2019). https://doi.org/10.1038/s41564-019-0467-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-019-0467-9

  • Springer Nature Limited

Search

Navigation