Skip to main content

Advertisement

SpringerLink
Log in

VIRAL CELL BIOLOGY

Stop HUSHing on SIV/HIV

  • News & Views
  • Published:

From Nature Microbiology

View current issue Submit your manuscript

Primate immunodeficiency virus accessory proteins Vpx/Vpr associate with and induce proteasomal degradation of the HUSH complex, thereby counteracting HUSH-mediated epigenetic transcriptional repression of proviral and cellular genes. These findings open new therapeutic avenues against HIV.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Model for HUSH-mediated epigenetic silencing of HIV-1 transcription during latency and Vpx/Vpr-mediated reactivation through HUSH complex degradation.

References

  1. Sauter, D. & Kirchoff, F. Cytokine Growth Factor Rev. 40, 3–12 (2018).

    Article  CAS  Google Scholar 

  2. Laguette, N. et al. Nature 474, 654–657 (2011).

    Article  CAS  Google Scholar 

  3. Hrecka, K. et al. Nature 474, 658–661 (2011).

    Article  CAS  Google Scholar 

  4. Chougui, G. et al. Nat. Microbiol. 3, 891–897 (2018).

    Article  CAS  Google Scholar 

  5. Yurkovetskiy, L. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0256-x (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Tchasovnikarova, I. A. et al. Science 348, 1481–1485 (2015).

    Article  CAS  Google Scholar 

  7. Liu, N. et al. Nature 553, 228–232 (2018).

    Article  CAS  Google Scholar 

  8. Tchasovnikarova, I. A. et al. Nat. Genet. 49, 1035–1044 (2017).

    Article  CAS  Google Scholar 

  9. McCarthy, K. R. & Johnson, W. E. PLoS Pathog. 10, e1004017 (2014).

    Article  Google Scholar 

  10. Jordan, A., Bisgrove, D. & Verdin, E. EMBO J. 22, 1868–1877 (2003).

    Article  CAS  Google Scholar 

  11. Khoury, G. et al. Adv. Exp. Med. Biol. 1075, 187–212 (2018).

    Article  CAS  Google Scholar 

  12. Imai, K., Togami, H. & Okamoto, T. J. Biol. Chem. 285, 16538–16545 (2010).

    Article  CAS  Google Scholar 

  13. Ding, D. et al. Virology 440, 182–189 (2013).

    Article  CAS  Google Scholar 

  14. du Chéné, I. et al. EMBO J. 26, 424–435 (2007).

    Article  Google Scholar 

  15. Marban, C. et al. EMBO J. 26, 412–423 (2007).

    Article  CAS  Google Scholar 

  16. Nguyen, K., Das, B., Dobrowolski, C. & Karn, J. mBio 8, e00133-17 (2017).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies, Belgium

    Carine Van Lint

Authors
  1. Carine Van Lint
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carine Van Lint.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Van Lint, C. Stop HUSHing on SIV/HIV. Nat Microbiol 3, 1336–1338 (2018). https://doi.org/10.1038/s41564-018-0308-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-018-0308-2

  • Springer Nature Limited

This article is cited by

Search

Navigation