The H445Y mutation in the β-subunit of RNA polymerase in Mycobacterium tuberculosis causes resistance to the antibiotic rifampicin and changes mycobacterial lipid composition. Infection with rpoB H445Y results in metabolic shifts that allow the bacteria to bypass a key host inflammatory response.
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Chen, YX., Javid, B. More than merely drug resistance. Nat Microbiol 3, 1078–1079 (2018). https://doi.org/10.1038/s41564-018-0250-3
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DOI: https://doi.org/10.1038/s41564-018-0250-3
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