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ANTIMICROBIAL RESISTANCE

TB drug susceptibility is more than MIC

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Genome-wide association studies and genetic analyses have identified a clinically prevalent alteration in the Mycobacterium tuberculosis genome that rewires bacterial propionate metabolism, conditionally reduces antibiotic killing without affecting minimum inhibitory concentrations, and may drive emergence of drug resistance.

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Fig. 1: prpR, a clinically prevalent and carbon-source-dependent drug-tolerance mutation in Mtb.

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  1. Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA

    Thomas Dick & Véronique Dartois

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  1. Thomas Dick
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  2. Véronique Dartois
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Correspondence to Thomas Dick or Véronique Dartois.

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The authors declare no competing interests.

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Dick, T., Dartois, V. TB drug susceptibility is more than MIC. Nat Microbiol 3, 971–972 (2018). https://doi.org/10.1038/s41564-018-0226-3

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