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ANTIMICROBIALS

Discovering antibiotics from the global microbiome

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Metagenomic sequencing, bioinformatic analysis and heterologous expression of an orphan biosynthetic gene cluster widely found in the environment led to the discovery and structural characterization of a novel group of calcium-dependent antibiotics hidden in plain sight.

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Fig. 1: Sequence-guided characterization of the malacidins.

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Authors and Affiliations

  1. Department of Chemistry, Chemical Biology Institute, Yale University, New Haven, CT, USA

    Yick Chong Lam & Jason M. Crawford

  2. Department of Microbial Pathogenesis at the Yale School of Medicine, New Haven, CT, USA

    Jason M. Crawford

Authors
  1. Yick Chong Lam
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  2. Jason M. Crawford
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Correspondence to Jason M. Crawford.

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The authors declare no competing interests.

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Lam, Y.C., Crawford, J.M. Discovering antibiotics from the global microbiome. Nat Microbiol 3, 392–393 (2018). https://doi.org/10.1038/s41564-018-0135-5

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