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Cancer nanomedicine

Exploiting endothelial transcytosis to reach into the brain

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Targeting P-selectin enables safer and more effective nanomedicine delivery through caveolin-1-mediated endothelial transcytosis in preclinical medulloblastoma tumour models.

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Fig. 1: Mechanism of nanoparticle transcytosis across the blood–brain barrier endothelium.

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Authors and Affiliations

  1. Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA

    Lin Wang & Stefan Wilhelm

  2. Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Stefan Wilhelm

  3. Institute for Biomedical Engineering, Science, and Technology (IBEST), University of Oklahoma, Norman, OK, USA

    Stefan Wilhelm

Authors
  1. Lin Wang
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  2. Stefan Wilhelm
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Correspondence to Stefan Wilhelm.

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The authors declare no competing interests.

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Wang, L., Wilhelm, S. Exploiting endothelial transcytosis to reach into the brain. Nat. Mater. 22, 282–283 (2023). https://doi.org/10.1038/s41563-023-01487-3

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