Skip to main content
SpringerLink
Log in

CELL MIGRATION

In search of a softer environment

  • News & Views
  • Published:

From Nature Materials

View current issue Submit your manuscript

By maximizing cell–substrate force transmission, cancer cells can migrate towards either stiffer or softer substrate regions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Mechanisms of durotaxis.
Fig. 2: Moving towards optimal forces.

References

  1. Lo, C. M. et al. Biophys J. 79, 144–152 (2000).

    Article  CAS  Google Scholar 

  2. Shellard, A. & Mayor, R. Nature 600, 690–694 (2021).

    Article  CAS  Google Scholar 

  3. Isomursu, A. et al. Nat. Mater. https://doi.org/10.1038/s41563-022-01294-2 (2022).

    Article  Google Scholar 

  4. Sunyer, R. et al. Science 353, 1157–1161 (2016).

    Article  CAS  Google Scholar 

  5. Shiu, J. Y. et al. Nat. Cell Biol. 20, 262–271 (2018).

    Article  CAS  Google Scholar 

  6. Elosegui-Artola, A. et al. Nat. Cell Biol. 18, 540–548 (2016).

    Article  CAS  Google Scholar 

  7. Chan, C. E. & Odde, D. J. Science 322, 1687–1691 (2008).

    Article  CAS  Google Scholar 

  8. Koser, D. E. et al. Nat. Neurosci. 19, 1592–1598 (2016).

    Article  CAS  Google Scholar 

  9. Elosegui-Artola, A., Trepat, X. & Roca-Cusachs, P. Trends Cell Biol. 28, 356–367 (2018).

    Article  CAS  Google Scholar 

  10. Bangasser, B. L. et al. Nat. Commun. 8, 15313 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physics, King’s College London, London, UK

    Amy E. M. Beedle

  2. Institute for Bioengineering of Catalonia, the Barcelona Institute of Technology, Barcelona, Spain

    Amy E. M. Beedle & Pere Roca-Cusachs

  3. Universitat de Barcelona, Barcelona, Spain

    Pere Roca-Cusachs

Authors
  1. Amy E. M. Beedle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pere Roca-Cusachs
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pere Roca-Cusachs.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Beedle, A.E.M., Roca-Cusachs, P. In search of a softer environment. Nat. Mater. 21, 995–996 (2022). https://doi.org/10.1038/s41563-022-01345-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41563-022-01345-8

  • Springer Nature Limited

Search

Navigation