Mutations in lamins in skeletal muscle cells have been shown to reduce nuclear stability, increase nuclear envelope rupture, and induce DNA damage and cell death. New research shows that limiting mechanical loads can rescue myofibre function and viability.
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We acknowledge V. Carranco (VCrea) for his contribution to the figure.
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Eissenberg, J.C., Gonzalo, S. Pushing the limit on laminopathies. Nat. Mater. 19, 378–380 (2020). https://doi.org/10.1038/s41563-020-0648-1
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DOI: https://doi.org/10.1038/s41563-020-0648-1
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