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CELL MIGRATION

Bringing order to the matrix

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Aligned anisotropic organization of the extracellular matrix by fibroblasts has now been shown to depend on cell reorientation following collision, with the cell collision guidance dependent on the transcription factor, TFAP2C.

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Fig. 1: Anisotropy of the ECM and collision guidance.

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Authors and Affiliations

  1. Department of Biomedical Engineering and the Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

    Paolo P. Provenzano

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  1. Paolo P. Provenzano
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Correspondence to Paolo P. Provenzano.

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Provenzano, P.P. Bringing order to the matrix. Nat. Mater. 19, 130–131 (2020). https://doi.org/10.1038/s41563-019-0592-0

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