Cancer cells have now been shown to lack rigidity-sensing due to alteration in cytoskeletal sensor proteins, but can be reversed from a transformed to a rigidity-dependent growth state by the sensor proteins, resulting in restoration of contractility and adhesion.
References
Yang, B. et al. Nat. Mater. https://doi.org/10.1038/s41563-019-0507-0 (2019).
Wolfenson, H. et al. Nat. Cell Biol. 18, 33–42 (2016).
Farag, A. K. & Roh, E. J. Med. Res. Rev. 39, 349–385 (2019).
Stehn, J. R., Schevzov, G., O’Neill, G. M. & Gunning, P. W. Curr. Cancer Drug Targets 6, 245–256 (2006).
Hendricks, M. & Weintraub, H. Proc. Natl Acad. Sci. USA 78, 5633–5637 (1981).
Gunning, P. W. & Hardeman, E. C. Curr. Biol. 27, R8–R13 (2017).
Pathan-Chhatbar, S. et al. J. Biol. Chem. 293, 863–875 (2018).
Sao, K. et al. Mol. Biol. Cell 30, 1170–1181 (2019).
Meiring, J. C. M. et al. Curr. Biol. 28, 2331–2337 (2018).
Meiring, J. C. M. et al. J. Cell Sci. 132, jcs228916 (2019).
Desouza-Armstrong, M., Gunning, P. W. & Stehn, J. R. Cytoskeleton 74, 233–248 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
E.C.H. and P.W.G. are directors and shareholders in TroBio Therapeutics Pty Ltd, a company commercializing the use of anti-tropomyosin drugs.
Rights and permissions
About this article
Cite this article
Hardeman, E.C., Gunning, P.W. Life and death agendas of actin filaments. Nat. Mater. 19, 135–136 (2020). https://doi.org/10.1038/s41563-019-0583-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41563-019-0583-1
- Springer Nature Limited
This article is cited by
-
Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation
Nature Materials (2022)
-
Morphological features of single cells enable accurate automated classification of cancer from non-cancer cell lines
Scientific Reports (2021)