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ACUTE KIDNEY INJURY

Enlightening kidney pathophysiology

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Understanding the mechanics of acute kidney injury from toxins, ischemia and sepsis remains challenging. Molecular probes with high renal clearance have now been developed for real-time optical detection of early-stage biomarkers of drug-induced acute kidney injury, and for the understanding of the mechanisms of injury.

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Fig. 1: Molecular renal probes for the detection of drug-induced acute kidney injury.
Fig. 2: The approaches conventially used in drug development for acute kidney injury.

References

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Authors and Affiliations

  1. National Institutes of Health, Bethesda, MD, USA

    Stephen M. Hewitt & Robert A. Star

  2. Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA

    Stephen M. Hewitt

  3. Renal Diagnostics and Therapeutics Unit, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA

    Robert A. Star

Authors
  1. Stephen M. Hewitt
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  2. Robert A. Star
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Correspondence to Stephen M. Hewitt.

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Hewitt, S.M., Star, R.A. Enlightening kidney pathophysiology. Nat. Mater. 18, 1034–1035 (2019). https://doi.org/10.1038/s41563-019-0490-5

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  • DOI: https://doi.org/10.1038/s41563-019-0490-5

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