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Stem cells

Mastering their own fates through the matrix

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With their ability to give rise to many different cell types, stem cells have long been a target of scientists who seek to achieve control over their differentiation. New evidence suggests that stem cells influence their own fates through protein deposition and physical remodelling of their microenvironment.

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Fig. 1: The role of ECM deposition and matrix remodelling in mesenchymal stromal cell (MSC) differentiation.

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Authors and Affiliations

  1. Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA

    Eric L. Qiao, Sanjay Kumar & David V. Schaffer

  2. Department of Bioengineering, University of California, Berkeley, CA, USA

    Sanjay Kumar & David V. Schaffer

Authors
  1. Eric L. Qiao
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  2. Sanjay Kumar
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  3. David V. Schaffer
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Correspondence to Sanjay Kumar or David V. Schaffer.

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Qiao, E.L., Kumar, S. & Schaffer, D.V. Mastering their own fates through the matrix. Nat. Mater. 18, 779–780 (2019). https://doi.org/10.1038/s41563-019-0429-x

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  • DOI: https://doi.org/10.1038/s41563-019-0429-x

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