Chiral amines possessing a stereogenic carbon atom bearing three carbon substituents and one nitrogen substituent are challenging structural motifs to prepare enantioselectively. Now, such motifs have been accessed in high enantiopurities by asymmetric Cu-catalysed propargylic amination using sterically confined ligands.
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Sieber, J.D. Copper catalysed asymmetric amination. Nat. Chem. 16, 483–484 (2024). https://doi.org/10.1038/s41557-024-01487-z
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DOI: https://doi.org/10.1038/s41557-024-01487-z
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