Single-particle cryo-electron microscopy and all-atom molecular dynamics simulations provide atomic details of ATP hydrolysis in the multimeric enzyme p97.
References
Gutteridge, A. & Thornton, J. FEBS Letters 567, 67–73 (2004).
Erzberger, J. P. & Berger, J. M. Annu. Rev. Biophys. Biomol. Struct. 35, 93–114 (2006).
Shein, M. et al. Nat. Chem. https://doi.org/10.1038/s41557-024-01440-0 (2024).
Richly, H. et al. Cell 120, 73–84 (2005).
Rabouille, C. et al. Cell 82, 905–914 (1995).
Ju, J. S. et al. J. Cell Biol. 187, 875–888 (2009).
Banerjee, S. et al. Science 351, 871–875 (2016).
Taylor, E. W. et al. Biochem. 9, 2984–2991 (1970).
Nam, K., Pu, J. & Karplus, M. Proc. Natl. Acad. Sci. USA 111, 17851–17865 (2014).
Ma, W. & Schulten, K. J. Am. Chem. Soc. 137, 3031–3040 (2015).
Priess, M. et al. ACS Cent. Sci. 4, 1334–1343 (2018).
Fernandez-Leiro, R. & Scheres, S. H. W. Nature 537, 339–346 (2016).
Torino, S. et al. Nat. Methods 20, 1400–1408 (2023).
Guaita, M., Watters, S. C. & Loerch, S. Curr. Opin. Struct. Biol. 77, 102484 (2022).
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Elghobashi-Meinhardt, N. ATP hydrolysis captured in atomic detail. Nat. Chem. 16, 306–307 (2024). https://doi.org/10.1038/s41557-024-01466-4
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DOI: https://doi.org/10.1038/s41557-024-01466-4
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