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Enzyme mechanisms

ATP hydrolysis captured in atomic detail

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Single-particle cryo-electron microscopy and all-atom molecular dynamics simulations provide atomic details of ATP hydrolysis in the multimeric enzyme p97.

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Fig. 1: The conformational dynamics of the N-terminal domain (NTD) of p97 throughout the ATP hydrolysis cycle are captured in atomic detail.

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Correspondence to Nadia Elghobashi-Meinhardt.

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Elghobashi-Meinhardt, N. ATP hydrolysis captured in atomic detail. Nat. Chem. 16, 306–307 (2024). https://doi.org/10.1038/s41557-024-01466-4

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