A method for carbon isotope exchange involving a metal-catalysed metathesis reaction of in situ formed acyl chlorides is demonstrated. The platform provides access to 13C- or 14C-enriched carboxylic acids, including natural products and pharmaceuticals, without the need for radioactive gases, using a single carboxylic acid carbon donor.
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References
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This is a summary of: Kinney, R. G. et al. A metal-catalysed functional group metathesis approach to the carbon isotope labelling of carboxylic acids. Nat. Chem. https://doi.org/10.1038/s41557-024-01447-7 (2024).
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Carbon isotope exchange for pharmaceutical radiolabelling through metal-catalysed functional group metathesis. Nat. Chem. 16, 489–490 (2024). https://doi.org/10.1038/s41557-024-01449-5
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DOI: https://doi.org/10.1038/s41557-024-01449-5
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