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Discovering cryptic natural products by substrate manipulation

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Cryptic halogenation reactions result in natural products with diverse structural motifs and bioactivities. However, these halogenated species are difficult to detect with current analytical methods because the final products are often not halogenated. An approach to identify products of cryptic halogenation using halide depletion has now been discovered, opening up space for more effective natural product discovery.

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Fig. 1: Overview of the state-of-the-art methods that were combined to discover cryptic natural products.

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Authors and Affiliations

  1. Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Institute for Bioinformatics and Medical Informatics (IBMI), University of Tübingen, Tübingen, Germany

    Ludek Sehnal, Libera Lo Presti & Nadine Ziemert

  2. Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany

    Ludek Sehnal, Libera Lo Presti & Nadine Ziemert

Authors
  1. Ludek Sehnal
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  2. Libera Lo Presti
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  3. Nadine Ziemert
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Correspondence to Nadine Ziemert.

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The authors declare no competing interests.

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Sehnal, L., Lo Presti, L. & Ziemert, N. Discovering cryptic natural products by substrate manipulation. Nat. Chem. 16, 149–151 (2024). https://doi.org/10.1038/s41557-023-01433-5

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