Skip to main content
Log in

Synthetic methodology

From feedstock to pharmaceuticals

  • News & Views
  • Published:

From Nature Chemistry

View current issue Submit your manuscript

Fluoroalkyl fragments are ubiquitous motifs in pharmaceuticals and agrochemicals, but their introduction to a given molecule typically involves expensive or difficult-to-handle reagents. Now, the photocatalysed hydrofluoroalkylation of alkenes has been achieved using simple and readily available fluoroalkyl carboxylic acids.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Iron photocatalysis enables the hydrofluoroalkylation of alkenes using fluoroalkyl carboxylic acids as reagents.

References

  1. Purser, S., Moore, P. R., Swallow, S. & Gouverneur, V. Chem. Soc. Rev. 37, 320–330 (2008).

    Article  PubMed  CAS  Google Scholar 

  2. Shibata, N., Matsnev, A. & Cahard, D. Beilstein J. Org. Chem. https://doi.org/10.3762/bjoc.6.65 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  3. López, S. E. & Salazar, J. J. Fluor. Chem. 156, 73–100 (2013).

    Article  Google Scholar 

  4. Depecker, C., Marzouk, H., Trevin, S. & Devynck, J. New J. Chem. 23, 739–742 (1999).

    Article  CAS  Google Scholar 

  5. Roth, H. G., Romero, N. A. & Nicewicz, D. A. Synlett. 27, 714–723 (2016).

    CAS  Google Scholar 

  6. Prier, C. K., Rankic, D. A. & MacMillan, D. W. C. Chem. Rev. 113, 5322–5363 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Xuan, J., Zhang, Z.-G. & Xiao, W.-J. Angew. Chem. Int. Ed. 54, 15632–15641 (2015).

    Article  CAS  Google Scholar 

  8. Bian, K.-J. et al. Nat. Chem. https://doi.org/10.1038/s41557-023-01365-0 (2023).

    Article  PubMed  Google Scholar 

  9. Juliá, F. ChemCatChem. 14, e2022009 (2022).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fabio Juliá.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Juliá, F. From feedstock to pharmaceuticals. Nat. Chem. 15, 1657–1658 (2023). https://doi.org/10.1038/s41557-023-01377-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41557-023-01377-w

  • Springer Nature Limited

Navigation