Tandem cycloaddition reactions have significant applications in organic synthetic chemistry. Now, two enzymes are shown to catalyse tandem hetero-Diels–Alder reactions with a synergistic interplay between a calcium cofactor and N-glycan post-translational modifications during the biosynthesis of bistropolone-sesquiterpene secondary metabolites.
References
Nicolaou, K. C., Synder, S. A., Montagnon, T. & Vassilikogiannakis, G. Angew. Chem. Int. Ed. 41, 1668–1698 (2002).
Liu, J. et al. Nat. Chem. https://doi.org/10.1038/s41557-023-01260-8 (2023).
Jeon, B.-S., Wang, S.-A., Ruszczycky, M. W. & Liu, H.-W. Chem. Rev. 117, 5367–5388 (2017).
Mayerl, F. et al. J. Antibiot. 46, 1082–1088 (1993).
Harris, G. H. et al. Tetrahedron 49, 2139–2144 (1993).
Chen, Q. et al. J. Am. Chem. Soc. 141, 14052–14056 (2019).
Schotte, C., Li, L., Wibberg, D., Kalinowski, J. & Cox, R. J. Angew. Chem. Int. Ed. 59, 23870–23878 (2020).
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Ushimaru, R., Abe, I. Back-to-back cycloadditions in nature. Nat. Chem. 15, 1056–1057 (2023). https://doi.org/10.1038/s41557-023-01282-2
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DOI: https://doi.org/10.1038/s41557-023-01282-2
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