Challenges in the synthesis of heparan sulfate (HS) glycosaminoglycans have limited access to defined HS oligosaccharides bearing a diverse array of sulfation sequences. A concise, divergent synthetic approach now provides a library of 64 HS tetrasaccharides displaying a comprehensive set of sulfation sequences, offering insight into the elusive sulfation code of glycosaminoglycans.
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This is a summary of: Wang, L. et al. Efficient platform for synthesizing comprehensive heparan sulfate oligosaccharide libraries for decoding glycosaminoglycan–protein interactions Nat. Chem. https://doi.org/10.1038/s41557-023-01248-4 (2023).
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Synthesis of oligosaccharide libraries for systematic explorations of heparan sulfate sequence space. Nat. Chem. 15, 1062–1063 (2023). https://doi.org/10.1038/s41557-023-01270-6
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DOI: https://doi.org/10.1038/s41557-023-01270-6
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