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Bringing amines back into aziridination

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Aziridines — three-membered nitrogen-containing heterocycles — are important synthetic targets, but N-alkyl aziridines are difficult to synthesize. Now, an electrochemical method, involving a dicationic intermediate, enables the coupling of alkenes and amines.

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Fig. 1: Development of a new strategy for aziridination synthesis.

References

  1. Gabriel, S. Chem. Ber. 21, 1049–1057 (1888).

    Article  Google Scholar 

  2. Sweeney, J. B. Chem. Soc. Rev. 31, 247–258 (2012).

    Article  Google Scholar 

  3. Guthikonda, K. & Du Bois, J. J. Am. Chem. Soc. 124, 13672–13673 (2002).

    Article  CAS  Google Scholar 

  4. Jat, J. L. et al. Science 343, 61–65 (2014).

    Article  CAS  Google Scholar 

  5. Holst, D. E., Wang, D. J., Kim, M. J., Guzei, I. A. & Wickens, Z. K. Nature 596, 74–79 (2021).

    Article  CAS  Google Scholar 

  6. Siu, T. & Yudin, A. K. J. Am. Chem. Soc. 124, 530–531 (2002).

    Article  CAS  Google Scholar 

  7. Berger, F. et al. Nature 567, 223–228 (2019).

    Article  CAS  Google Scholar 

  8. Yan, M., Kawamata, Y. & Baran, P. S. Chem. Rev. 117, 13230–13319 (2017).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Louis-Charles Campeau.

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Piou, T., Campeau, LC. Bringing amines back into aziridination. Nat. Chem. 13, 1027–1028 (2021). https://doi.org/10.1038/s41557-021-00819-7

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