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PEPTIDE LIBRARIES

Combining biological and chemical diversity

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Phage display enables screening of billions of peptides comprised mainly of natural amino acids. Now, a method to attach and encode a range of structurally diverse compounds has been reported. This method can expand the chemical space covered by phage display peptide libraries.

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Fig. 1: Illustration of the approach to diversify phage-encoded peptide libraries by appending chemical compounds.

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  1. Institute of Chemical Sciences and Engineering, École Polytechnique Fédéral de Lausanne, Lausanne, Switzerland

    Christian Heinis

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  1. Christian Heinis
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Correspondence to Christian Heinis.

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Heinis, C. Combining biological and chemical diversity. Nat. Chem. 13, 512–513 (2021). https://doi.org/10.1038/s41557-021-00722-1

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