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Stem cells

It takes two to expand the cortex

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Two new landmark studies use innovative and complementary lineage tracing approaches in human cerebral organoids to reveal symmetric stem cell division and direct neurogenesis of basal radial glial cells to enable cortical growth, expansion and differentiation.

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Fig. 1: Human-specific stem cell modalities engaged in cortical expansion.

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Correspondence to Yechiel Elkabetz.

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Elkabetz, Y. It takes two to expand the cortex. Nat Cell Biol 26, 667–669 (2024). https://doi.org/10.1038/s41556-024-01416-9

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