Two new landmark studies use innovative and complementary lineage tracing approaches in human cerebral organoids to reveal symmetric stem cell division and direct neurogenesis of basal radial glial cells to enable cortical growth, expansion and differentiation.
References
Sousa, A. M. M. et al. Cell 170, 226–247 (2017).
Fietz, S. A. et al. Nat. Neurosci. 13, 690–699 (2010).
Hansen, D. V., Lui, J. H., Parker, P. R. & Kriegstein, A. R. Nature 464, 554–561 (2010).
Pollen, A. A. et al. Cell 163, 55–67 (2015).
Velasco, S. et al. Nature 570, 523–527 (2019).
Uzquiano, A. et al. Cell 185, 3770–3788.e3727 (2022).
Rosebrock, D. et al. Nat. Cell Biol. 24, 981–995 (2022).
Lindenhofer, D. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01412-z (2024).
Coquand, L. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01393-z (2024).
Casas Gimeno, G. & Paridaen, J. T. M. L. Front. Cell Dev. Biol. 10, 885269 (2022).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests
Rights and permissions
About this article
Cite this article
Elkabetz, Y. It takes two to expand the cortex. Nat Cell Biol 26, 667–669 (2024). https://doi.org/10.1038/s41556-024-01416-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-024-01416-9
- Springer Nature Limited