Diverse, specialized immune cells defend against pathogens and cancer cells. A new study reveals the comprehensive lipid compositions of these cells, with unique lipidomes associated with various immune cell types. They show that cell-specific lipid compositions determine a key functional phenotype: their susceptibility to ferroptosis.
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References
Morgan, P. K. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01377-z (2024).
Wallin, E. & von Heijne, G. Protein Sci. 7, 1029–1038 (1998).
Zhang, C. et al. Sci. Rep. 7, 412 (2017).
Levental, K. R. et al. Sci. Adv. 3, eaao1193 (2017).
Symons, J. L. et al. Soft Matter 17, 288–297 (2020).
Doll, S. et al. Nat. Chem. Biol. 13, 91–98 (2017).
Phadnis, V. V. et al. Cell Rep. 42, 113023 (2023).
Zou, Y. et al. Nature 585, 603–608 (2020).
Dixon, S. J. et al. Cell 149, 1060–1072 (2012).
Kagan, V. E. et al. Nat. Chem. Biol. 13, 81–90 (2017).
Drijvers, J. M. et al. Cancer Immunol. Res. 9, 184–199 (2021).
Xu, C. et al. Cell Rep. 35, 109235 (2021).
Muri, J., Thut, H., Bornkamm, G. W. & Kopf, M. Cell Rep. 29, 2731–2744 (2019).
Kapralov, A. A. et al. Nat. Chem. Biol. 16, 278–290 (2020).
Pinot, M. et al. Science 345, 693–697 (2014).
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Levental, K.R., Henry, W.S. Lipidomes define immune cell identity. Nat Cell Biol 26, 516–518 (2024). https://doi.org/10.1038/s41556-024-01398-8
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DOI: https://doi.org/10.1038/s41556-024-01398-8
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