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Nuclear organization

Transcriptional bodies manage tight resources

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Eukaryotic transcriptional machinery often shows local enrichment in dynamic clusters at sites of high expression. A study of zebrafish embryos shows that such clusters can fine-tune the timing of zygotic genome activation by sequestering a component required for productive transcription, thus limiting its availability to other genes.

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Fig. 1: The high transcriptional activity at the miR430 locus sequesters CDK9, preventing it from untimely activation of poised genes.

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Authors and Affiliations

  1. Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland

    Natalia Stec & Adam Klosin

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  1. Natalia Stec
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  2. Adam Klosin
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Correspondence to Adam Klosin.

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The authors declare no competing interests.

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Stec, N., Klosin, A. Transcriptional bodies manage tight resources. Nat Cell Biol 26, 512–513 (2024). https://doi.org/10.1038/s41556-024-01395-x

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