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Mechanobiology

Tissue pressure and YAP during organogenesis

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Organ morphogenesis begins with proliferation, which results in tissue pressures and site-specific YAP expression, nuclear translocation and signalling. A study now reports the involvement of anisotropy, localized pressure and YAP signalling in organizer-forming cascades, introducing a new chapter of molecular mechanobiology of organogenesis.

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Fig. 1: Tissue mechanics drive enamel knot formation in the mouse incisor.

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Acknowledgements

Generous funding by NIDCR grants DE026198 and DE027930 to T.G.H.D. is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Oral and Craniofacial Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

    Qian Xu & Thomas G. H. Diekwisch

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  1. Qian Xu
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  2. Thomas G. H. Diekwisch
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Correspondence to Thomas G. H. Diekwisch.

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The authors declare no competing interests.

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Xu, Q., Diekwisch, T.G.H. Tissue pressure and YAP during organogenesis. Nat Cell Biol 26, 510–511 (2024). https://doi.org/10.1038/s41556-024-01392-0

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