Contractile activity of both the epithelium and underlying mesenchyme are required for epithelial deformation and cell fate acquisition during early mouse hair follicle development. Subsequently, localized basement membrane remodelling facilitates the release of tension-generated pressure to promote cell divisions, tissue fluidification and downgrowth of the developing hair follicle.
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References
Collinet, C. & Lecuit, T. Programmed and self-organized flow of information during morphogenesis. Nat. Rev. Mol. Cell Biol. 22, 245–265 (2021). A review article that discusses the spatiotemporal relationship between cell mechanics and the associated cell behaviours during tissue morphogenesis.
Schmidt-Ullrich, R. & Paus, R. Molecular principles of hair follicle induction and morphogenesis. Bioessays 27, 247–261 (2005). A review article that describes hair follicle development.
Barbazan, J. et al. Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction. Nat. Commun. 14, 6966 (2023). This article describes the response of cancer cells to mechanical compression from the surrounding fibroblasts.
Bansaccal, N. et al. The extracellular matrix dictates regional competence for tumour initiation. Nature 623, 828–835 (2023). This article shows the effect of extracellular matrix mechanics on tumour initiation.
Parada, C. et al. Mechanical feedback defines organizing centers to drive digit emergence. Dev. Cell 57, 854–866 (2022). This article implicates mechanical regulation of SOX9 expression in mouse digit development.
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This is a summary of: Villeneuve, C. et al. Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01332-4 (2024).
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Contractility drives the spatio-temporal coordination of morphogenesis and cell fate in hair follicles. Nat Cell Biol 26, 325–326 (2024). https://doi.org/10.1038/s41556-024-01371-5
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DOI: https://doi.org/10.1038/s41556-024-01371-5
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