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ER remodelling by ER-phagy in neurogenesis

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The endoplasmic reticulum (ER) controls the synthesis of lipids and proteins and Ca2+ homeostasis, as well as contacting other organelles and the plasma membrane. A study now looks at a process by which this compartment is remodelled in axons during neurogenesis: the lysosomal clearance of ER subdomains, driven by FAM134 and CCPG1 proteins.

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Fig. 1: ER-phagy in the neuronal axon.

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Authors and Affiliations

  1. Università della Svizzera italiana, Institute for Research in Biomedicine, Bellinzona, Switzerland

    Maurizio Molinari

  2. School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

    Maurizio Molinari

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  1. Maurizio Molinari
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Correspondence to Maurizio Molinari.

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Molinari, M. ER remodelling by ER-phagy in neurogenesis. Nat Cell Biol 26, 316–317 (2024). https://doi.org/10.1038/s41556-024-01362-6

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