Despite a growing understanding of the immunostimulatory properties of mitochondrial DNA (mtDNA), little is known about how and why mtDNA escapes its mitochondrial confines. A study now describes an endosomal trafficking pathway that facilitates mtDNA egress and provides an additional mechanism of mtDNA release in vitro.
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McArthur, K., Kile, B.T. mtDNA caught in the act again. Nat Cell Biol 26, 177–178 (2024). https://doi.org/10.1038/s41556-024-01345-7
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DOI: https://doi.org/10.1038/s41556-024-01345-7
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