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Nuclear condensates

FUS maintains TAZ fluidity and function

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The transcriptional coactivators TAZ and YAP pair with transcriptional enhanced associate domains (TEADs) to regulate transcription. TAZ and YAP nuclear condensates ensure optimal transcription. A new study reports that FUS regulates TAZ condensates by maintaining them in a fluid state to drive transcription of target genes.

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Fig. 1: FUS regulates the fluidity of TAZ nuclear condensates.

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Authors and Affiliations

  1. Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    Wanjin Hong

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  1. Wanjin Hong
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Correspondence to Wanjin Hong.

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Hong, W. FUS maintains TAZ fluidity and function. Nat Cell Biol 26, 34–36 (2024). https://doi.org/10.1038/s41556-023-01318-2

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