Skip to main content
SpringerLink
Log in

Metabolism

EPAC1 boosts thermogenic adipocyte formation

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

β-adrenergic signalling induces thermogenesis in mature brown adipocytes through a well-known cAMP–protein kinase A (PKA) pathway and also promotes the growth and differentiation of new thermogenic adipocytes. A study now demonstrates that β-adrenergic agonists drive this pathway through a PKA-independent mechanism involving cAMP–EPAC1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Sympathetic stimulation induces brown fat activation and differentiation through PKA-dependent and PKA-independent pathways, respectively.

References

  1. Cohen, P. & Kajimura, S. Nat. Rev. Mol. Cell Biol. 22, 393–409 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Roh, H. C. et al. Cell Metab. 27, 1121–1137.e1125 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Becher, T. et al. Nat. Med. 27, 58–65 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Rosen, E. D. & MacDougald, O. A. Nat. Rev. Mol. Cell Biol. 7, 885–896 (2006).

    Article  CAS  PubMed  Google Scholar 

  5. Lee, K. BMB Rep. 54, 149–156 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Reverte-Salisa, L. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01311-9 (2024).

    Article  PubMed  Google Scholar 

  7. Fukuda, M., Williams, K. W., Gautron, L. & Elmquist, J. K. Cell Metab. 13, 331–339 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kai, A. K. et al. FASEB J. 27, 4122–4135 (2013).

  9. Yan, J. et al. Mol. Cell Biol. 33, 918–926 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Evan D. Rosen

Authors
  1. Evan D. Rosen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Evan D. Rosen.

Ethics declarations

Competing interests

E.D.R. consults for Novartis and is on the Advisory Board of Source Bio.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rosen, E.D. EPAC1 boosts thermogenic adipocyte formation. Nat Cell Biol 26, 39–40 (2024). https://doi.org/10.1038/s41556-023-01304-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-023-01304-8

  • Springer Nature Limited

Search

Navigation