YTHDF family members are ‘readers’ of a common mRNA modification, but their effects on mRNA translation and stability have been disputed. A new study shows that YTHDF1 and YTHDF3 are post-translationally regulated through O-GlcNAcylation, unifying disparate results and pointing to environmental cues that could modulate YTHDF function.
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We thank Y. Nam for comments on the manuscript.
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Burns, M.W.N., Kohler, J.J. O-GlcNAc regulates YTHDF1 and YTHDF3 activity. Nat Cell Biol 25, 1570–1572 (2023). https://doi.org/10.1038/s41556-023-01275-w
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DOI: https://doi.org/10.1038/s41556-023-01275-w
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