How spatial organization in the cell is achieved on the organelle scale is unclear. A new study finds that tethering specific proteins near the surface of micelle-like paraspeckles modifies their properties and determines whether these subnuclear organelles are separate from, adhere to, or are engulfed by nuclear speckles.
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References
Sawyer, I. A. et al. Wiley Interdiscip. Rev. RNA 10, e1514 (2019).
Takakuwa, H. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01254-1 (2023).
Guillén-Boixet, J. et al. Cell 181, 346–361 (2020).
Spector, D. L. & Lamond, A. I. Cold Spring Harb. Perspect. Biol. 3, a000646 (2011).
Tammer, L. et al. Mol. Cell 82, 1021–1034 (2022).
Hochberg-Laufer, H. et al. PLOS Genet. 15, e1008459 (2019).
Shevtsov, S. P. & Dundr, M. Nat. Cell Biol. 13, 167–173 (2011).
Decker, C. J. et al. EMBO J. 41, e110137 (2022).
Yamazaki, T. et al. EMBO J. 40, e107270 (2021).
Yamazaki, T. et al. Mol. Cell 70, 1038–1053 (2018).
Suzuki, H. et al. Nat. Commun. 13, 2905 (2022).
Barutcu, A. R. et al. Mol. Cell 82, 1035–1052 (2022).
Bhandari, K. et al. J. Phys. Chem. B 125, 467–476 (2021).
Schmit, J. D. et al. Trends Biochem. Sci. 46, 525–534 (2021).
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Schmit, J.D., Dundr, M. Keeping membraneless organelles apart. Nat Cell Biol 25, 1566–1567 (2023). https://doi.org/10.1038/s41556-023-01265-y
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DOI: https://doi.org/10.1038/s41556-023-01265-y
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