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Saving ribosomal proteins for later

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Disruption of ribosome assembly results in the accumulation of aggregation-prone ‘orphaned’ ribosomal proteins that are toxic to cells if left unchecked. A study finds that cells store such ribosomal proteins during heat shock to enable a quick recovery of ribosome assembly after the removal of this stress.

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Fig. 1: Chaperones store orphaned ribosomal proteins at the nucleolar periphery during heat shock stress.

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Correspondence to Rachel Green.

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Competing interests

R.G. is a member of the scientific advisory board of Alltrna, Initial Therapeutics and Arrakis Pharmaceuticals and serves as a consultant to Vertex Pharmaceuticals, Brystol-Myers Squibb (Celgene), Monta Rosa Therapeutics and Flagship Pioneering. R.G. previously served on the scientific advisory board at Moderna. J.J.B. declares no competing interests.

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Black, J.J., Green, R. Saving ribosomal proteins for later. Nat Cell Biol 25, 1568–1569 (2023). https://doi.org/10.1038/s41556-023-01251-4

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