ESCRT-III seals holes in the nuclear envelope (NE). A study now shows that the Cmp7-directed ESCRT-III cascade that grommets and reseals NE holes after spindle pole body (SPB) extrusion at the end of fission yeast mitosis is complemented by the presence of a proteinaceous diffusion barrier to ensure NE integrity.
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Shah, H., Dey, G. A diffusion barrier limits nuclear leaks. Nat Cell Biol 25, 1411–1412 (2023). https://doi.org/10.1038/s41556-023-01243-4
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DOI: https://doi.org/10.1038/s41556-023-01243-4
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