Skip to main content
Log in

Stem cells

The epicentre of haematopoiesis and osteogenesis

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Bone marrow endothelial cells deliver oxygen and nutrients and regulate bone formation and haematopoiesis in the surrounding microenvironment. A new study identifies a subtype of capillary that occurs exclusively in the epiphysis and displays unique characteristics that have a role in balancing osteogenesis and haematopoiesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Type S vessels in the epiphyseal bone marrow balance osteogenesis and haematopoiesis.

References

  1. Butler, J. M. et al. Cell Stem Cell 6, 251–264 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Lis, R. et al. Nature 545, 439–445 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Rafii, S., Butler, J. M. & Ding, B. Sen Nature 529, 316–325 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Tikhonova, A. N. et al. Nature 569, 222 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Baryawno, N. et al. Cell 177, 1915–1932.e16 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hooper, A. T. et al. Cell Stem Cell 4, 263–274 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Iga, T. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01240-7 (2023).

    Article  PubMed  Google Scholar 

  8. Baccin, C. et al. Nat. Cell Biol. 22, 38–48 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Chen, Y. et al. Nat. Commun. 12, 7199 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kusumbe, A. P., Ramasamy, S. K. & Adams, R. H. Nature 507, 323–328 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Ramasamy, S. K. et al. Nat. Commun. 7, 13601 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shahin Rafii.

Ethics declarations

Competing interests

S.R. is co-founder and non-paid consultant to Angiocrine Bioscience. D.R. declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Redmond, D., Rafii, S. The epicentre of haematopoiesis and osteogenesis. Nat Cell Biol 25, 1406–1407 (2023). https://doi.org/10.1038/s41556-023-01242-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-023-01242-5

  • Springer Nature Limited

Navigation